We have characterized genomic differences between primary and metastatic cancers across a range of cancer types, evaluating tumor heterogeneity through space and time. We developed new analytic approaches to show that, for endometrial cancers, metastases tend to arise from a single clone within the primary tumor. We also have made extensive efforts to characterize the changes that brain tumors undergo through conventional and novel treatments to probe mechanisms of treatment resistance and how to overcome them. These efforts include single-cell DNA and RNA sequencing and development of new tools, such as novel cell barcoding approaches to dissect the evolution of cell populations through time.
Developing computational approaches to interpret cancer genomes | Comprehensive genomic characterization of brain cancers
