A suite of papers evaluating whole genome sequencing data across ~2700 cancers was published today. This was an international collaborative effort; the Beroukhim lab helped lead two of these papers. Patterns of somatic structural variation in human cancer genomes, Nature, February 2020, and Analyses of non-coding somatic drivers in 2,658 cancer whole genomes, Nature, February 2020.

The Beroukhim and Golub laboratories published a paper indicating how extensively cell lines can evolve over time and diverge across laboratories.  The paper was featured on the journal’s cover.  Nature, August 2018.

Former postdoc Linda Bi has now established an independent laboratory in the Department of Neurosurgery at Brigham and Women’s Hospital, as an Assistant Professor at Harvard Medical School. She is focused on tumors of the skull base.

The Beroukhim laboratory published a new tool to detect rearrangements in DNA sequencing data, with improved accuracy over prior methods. Genome Research, April 2018.

The Beroukhim and Golub laboratories published a paper demonstrating substantial evolution of human tumor xenografts in mice.  The paper received coverage in Nature News, Ars Technica, and The Scientist.  Nature Genetics, October 2017.

A new research grant award from St. Baldrick’s Foundation is supporting the Beroukhim Lab’s research in intratumoral heterogeneity of resistance drivers in diffuse intrinsic pontine gliomas (DIPG) to help determine how DIPG becomes resistant to treatments.

The Beroukhim Lab recently published the largest clinical study to date of genetic abnormalities in pediatric brain tumors, demonstrating that testing pediatric brain tumor tissue for genetic abnormalities is clinically feasible and can guide patients’ treatment. Neuro-Oncology, May 2017.