The Beroukhim and Taylor labs published a paper describing a new algorithm to decipher the effects of aneuploidies on evolutionary selection, and the results of its application to over 10,000 cancers. Nature, June 2023.

The Beroukhim and Boehm labs have posted a preprint describing a common CRISPR artifact that is most prevalent in people of African ancestry. The preprint was featured by Science News, November 2022.

The Dana-Farber Cancer Institute Postdoctoral and Graduate student Association (PGA) named Rameen as Mentor of the Year for 2022.

The Beroukhim and Weischenfeldt labs published a review on the influence of 3D genome organization on structural variations in cancer. Nature Reviews Cancer, September 2022.

The Beroukhim and Bandopadhayay labs published a paper describing structural variants in pediatric high-grade gliomas, including signatures associated with different histone mutations. Nature Cancer, August 2022.

The Beroukhim laboratory performed a systematic exploration of potential therapeutic vulnerabilities deriving from loss of heterozygosity in cancer. Nature Communications, May 2020. Caitlin Nichols, who led the study, gave a great presentation on it as a Harvard Horizons Fellow.

A study led by current and former Beroukhim lab members, in collaboration with the Golub lab, found that CAS9 expression alone activates the p53 pathway and spurs cell line evolution. These have implications for experiments making use of CAS9. Nature Genetics, May 2020.

The Beroukhim lab led a TCGA-based effort to evaluate the molecular differences between ancestries across 33 cancer types–the largest and most comprehensive such analysis in diseased or non-diseased tissue, with implications for both. Cancer Cell, May 2020.

The Beroukhim, Bandopadhayay, Bielle, and Ligon labs published a paper describing the evolutionary processes that lead to hypermutation in gliomas, and their therapeutic implications. Nature, April 2020.

Former postdoc Uri Ben-David has now established an independent laboratory in the Department of Human Molecular Genetics and Biochemistry at Tel Aviv University. He is focused on studying the consequences of aneuploidy.