Developing computational approaches to interpret cancer genomes | Comprehensive genomic characterization of brain cancers

BEROUKHIM
LAB

Research

The Beroukhim Lab’s work focuses on understanding the genetic changes that occur through cancer evolution and how these changes affect cancer behavior. We have particular interests in brain cancers and in alterations of chromosome structure (rearrangements and copy number changes) across many cancers. We have also had longstanding efforts in endometrial cancers. We have research activities in the following areas:

Developing and applying computational methods to analyze large genomic datasets

We have developed computational approaches to detect copy-number alterations and rearrangements frommore infoDeveloping and applying computational methods to analyze large genomic datasets

Identifying novel cancer vulnerabilities associated with copy-number change

Through integrated analyses of genetic and functional genomic data, wemore infoIdentifying novel cancer vulnerabilities associated with copy-number change

Performing comprehensive genomic analyses of brain cancers in both adults and children

We identified SMO and AKT1 mutations in meningiomas, leading to internationalmore infoPerforming comprehensive genomic analyses of brain cancers in both adults and children

Studying tumor evolution

We have characterized genomic differences between primary and metastatic cancersmore infoStudying tumor evolution

Recent News

The effects of aneuploidy on evolutionary selectionAugust 1, 2023

The Beroukhim and Taylor labs published a paper describing a new algorithm to decipher the effects of aneuploidies on evolutionary selection, and the results of its application to over 10,000 cancers. Nature, June 2023.
Effects of Ancestry on CRISPR experimentsNovember 30, 2022

The Beroukhim and Boehm labs have posted a preprint describing a common CRISPR artifact that is most prevalent in people of African ancestry. The preprint was featured by Science News, November 2022.
Rameen receives “Mentor of the Year” awardOctober 7, 2022

The Dana-Farber Cancer Institute Postdoctoral and Graduate student Association (PGA) named Rameen as Mentor of the Year for 2022.