A comprehensive study of cell line evolution
The Beroukhim and Golub laboratories published a paper indicating how extensively cell lines can evolve over time and diverge across laboratories. The paper was featured on the journal’s cover. Nature, August 2018.
Linda Bi establishes her own lab
Former postdoc Linda Bi has now established an independent laboratory in the Department of Neurosurgery at Brigham and Women’s Hospital, as an Assistant Professor at Harvard Medical School. She is focused on tumors of the skull base.
SvABA: an assembly-based rearrangement detection tool
The Beroukhim laboratory published a new tool to detect rearrangements in DNA sequencing data, with improved accuracy over prior methods. Genome Research, April 2018.
Lab publishes study of evolution in PDX models
The Beroukhim and Golub laboratories published a paper demonstrating substantial evolution of human tumor xenografts in mice. The paper received coverage in Nature News, Ars Technica, and The Scientist. Nature Genetics, October 2017.
Beroukhim Lab receives St. Baldrick’s Foundation grant
A new research grant award from St. Baldrick’s Foundation is supporting the Beroukhim Lab’s research in intratumoral heterogeneity of resistance drivers in diffuse intrinsic pontine gliomas (DIPG) to help determine how DIPG becomes resistant to treatments.
Lab publishes largest study to date of genetic abnormalities in pediatric brain tumors
The Beroukhim Lab recently published the largest clinical study to date of genetic abnormalities in pediatric brain tumors, demonstrating that testing pediatric brain tumor tissue for genetic abnormalities is clinically feasible and can guide patients’ treatment. Neuro-Oncology, May 2017.